Monoclonal and Polyclonal Antibodies Research
연구주제 · Radiology, Nuclear Medicine and Imaging
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A synthetic library for rapid isolation of humanized single-domain ant · Isolation and characterization of single domain antibodies from banded · Structural Study on the Impact of S239D/I332E Mutations in the Binding · Escherichia coli inner membrane display system for high‐throughput scr · Engineering FcRn binding kinetics dramatically extends antibody serum · Engineered neutrophil engagers overcome IgA limitations and reprogram · Engineered aglycosylated full-length IgG Fc variants exhibiting improv · Development of Single‐Chain Antibodies Specific to Lysophosphatidic Ac · Engineering antibodies for dual specificity and enhanced potency · The Highly Evolvable Antibody Fc Domain · Engineering an aglycosylated Fc variant for enhanced FcγRI engagement · Isolation of Single Chain Antibodies Specific to Lysophosphatidic Acid · Engineered human FcγRIIa fusion: A novel strategy to extend serum half · Unlocking the Power of Complement-Dependent Cytotoxicity: Engineering · An Fc variant with two mutations confers prolonged serum half-life and · Structural consequences of aglycosylated IgG Fc variants evolved for F · Design of an Fc Mutation to Abrogate Fcγ Receptor Binding Based on Res · Reprogramming the Constant Region of Immunoglobulin G Subclasses for E · Effective clearance of rituximab-resistant tumor cells by breaking the · High-resolution antibody dynamics of vaccine-induced immune responses · Antigen Design for Successful Isolation of Highly Challenging Therapeu · Engineered Human Antibody with Improved Endothelin Receptor Type A Bin · Boosting therapeutic potency of antibodies by taming Fc domain functio · A human antibody against human endothelin receptor type A that exhibit · Precision Fc remodeling via glycosylation-competent CHO display enable · Optimal combination of beneficial mutations for improved ADCC effector · Advanced human FcRn knock-in mice for pharmacokinetic profiling of the · Aglycosylated full-length IgG antibodies: steps toward next-generation · Escherichia coli and Pichia pastoris : microbial cell-factory platform · Computer‐based engineering of thermostabilized antibody fragments · Recent Achievements and Challenges in Prolonging the Serum Half-Lives · A stealth-body Fc engineering platform enables complete effector silen