SNU CBE

대장균 escherichia coli

키워드 · 생명공학·합성생물학

20학부 논문
2교수
186억 국가 R&D(2015–24)
신규증가율
3.24%서울대 비중

유전체가 잘 밝혀진 대표 모델 세균으로, 전사조절 연구와 재조합 단백질·화학물 생산 숙주로 쓰인다.

연도별 학부 논문

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국가 R&D 과제 동향 (NTIS, 억 원)

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2015–2024 과제 레코드 148건 · 10년 186억 · 2015–19 대비 2020–24 신규 · 대학 수행 56.3% · 서울대(본교) 3.24%. 매칭: 영문 키워드 'escherichia coli'. 기관운영비·인력양성·출연연 주요사업비 등 과제 아닌 레코드는 뺐다.

매칭 과제의 NTIS 표준분류(1순위, 연구비 비중): 보건의료 > 신약·의약품개발 33% · 생명과학 > 생물공학 13% · 생명과학 > 분자세포생물학 9% · 보건의료 > 의생명과학 7%

최근 주요 과제 (2022–2024, 연차 정부연구비 순)

연도과제수행기관부처억
2022박테리오파지 기반 다제내성 녹농균 및 대장균 치료제 생산시설 구축, 전임상 및 임상시험(주)마이크로바이오틱스보건복지부9.0
2022노로바이러스장염 VLP형 다가 예방 백신 개발(주)인테라보건복지부6.0
2023다제내성세균 감염 요로감염증 치료를 위한 박테리오파지 제제 개발(주)마이크로바이오틱스산업통상자원부5.0
2023단백질 나노입자 기반 지카바이러스 합성항원 백신 후보물질의 개발(주)인테라보건복지부3.5
2023단백질 나노 파티클 기반 뎅기 바이러스 합성 항원 백신 후보 물질 개발(주)인테라보건복지부3.5
2023단백질 나노파티클 기반 재조합 지카백신 후보물질 효능평가성신여자대학보건복지부2.5
2023단백질 나노파티클 기반 뎅기백신 후보물질의 효능 평가성신여자대학보건복지부2.5
2023미생물 생산기반 자가조립 코로나19 나노입자백신 제작기술 개발가톨릭대학과학기술정보통신부2.5

교수

교수연구분야논문2022년 이후
서상우생물 및 환경187
한지숙생물 및 환경21

함께 나오는 키워드

전사조절 네트워크 유전체 규모 대사 모델(GEM) 카다베린 생산 대사공학 질소 제한 단백질-단백질 상호작용

연결되는 NTIS 분류

없음

논문 (최신순)

연도논문학부 저자피인용
2025Direct Quantification of Protein–Protein Interactions in Living Bacterial Cells
Advanced Science
한지숙5
2025Promoter-proximal transcription–translation coupling controls early transcription in Escherichia coli
Nucleic Acids Research
서상우2
2025Integrated Tn-seq and MAGE-assisted rapid genome engineering targeting in Escherichia coli
Trends in biotechnology
서상우2
2024Synthetic redesign of Escherichia coli W for faster metabolism of sugarcane molasses
Microbial Cell Factories
서상우12
2024Dynamic control of the plasmid copy number maintained without antibiotics in Escherichia coli
Journal of Biological Engineering
서상우6
2023CRISPRi-mediated tunable control of gene expression level with engineered single-guide RNA in Escherichia coli
Nucleic Acids Research
서상우43
2023Model-driven experimental design workflow expands understanding of regulatory role of Nac in Escherichia coli
NAR Genomics and Bioinformatics
서상우7
2022Revealing Causes for False-Positive and False-Negative Calling of Gene Essentiality in Escherichia coli Using Transposon Insertion Sequencing
mSystems
서상우18
2020Independent component analysis of E. coli's transcriptome reveals the cellular processes that respond to heterologous gene expression
Metabolic Engineering
서상우44
2019Cellular responses to reactive oxygen species are predicted from molecular mechanisms
Proceedings of the National Academy of Sciences
서상우119
2018Systematic discovery of uncharacterized transcription factors in Escherichia coli K-12 MG1655
Nucleic Acids Research
서상우102
2018Synthetic auxotrophs for stable and tunable maintenance of plasmid copy number
Metabolic Engineering
서상우72
2017Precise flux redistribution to glyoxylate cycle for 5-aminolevulinic acid production in Escherichia coli
Metabolic Engineering
서상우76
2017Revealing genome-scale transcriptional regulatory landscape of OmpR highlights its expanded regulatory roles under osmotic stress in Escherichia coli K-12 MG1655
Scientific Reports
서상우49
2017Synthetic redesign of Escherichia coli for cadaverine production from galactose
Biotechnology for Biofuels
서상우41
2016Application of SGT1-Hsp90 chaperone complex for soluble expression of NOD1 LRR domain in E. coli
Biochemical and Biophysical Research Communications
한지숙9
2015Genome-wide Reconstruction of OxyR and SoxRS Transcriptional Regulatory Networks under Oxidative Stress in Escherichia coli K-12 MG1655
Cell Reports
서상우237
2015Decoding genome-wide GadEWX-transcriptional regulatory networks reveals multifaceted cellular responses to acid stress in Escherichia coli
Nature Communications
서상우104
2015Pathway optimization by re-design of untranslated regions for L-tyrosine production in Escherichia coli
Scientific Reports
서상우61
2014Deciphering Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli
Nature Communications
서상우321

인접 그래프

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교수 2

서상우 · 한지숙

논문 20

Model-driven experimental design workflow expands understanding of reg · Synthetic redesign of Escherichia coli for cadaverine production from · Integrated Tn-seq and MAGE-assisted rapid genome engineering targeting · Revealing Causes for False-Positive and False-Negative Calling of Gene · Decoding genome-wide GadEWX-transcriptional regulatory networks reveal · Deciphering Fur transcriptional regulatory network highlights its comp · Systematic discovery of uncharacterized transcription factors in Esche · Direct Quantification of Protein–Protein Interactions in Living Bacter · Cellular responses to reactive oxygen species are predicted from molec · Revealing genome-scale transcriptional regulatory landscape of OmpR hi · Genome-wide Reconstruction of OxyR and SoxRS Transcriptional Regulator · Independent component analysis of E. coli's transcriptome reveals the · CRISPRi-mediated tunable control of gene expression level with enginee · Dynamic control of the plasmid copy number maintained without antibiot · Promoter-proximal transcription–translation coupling controls early tr · Synthetic redesign of Escherichia coli W for faster metabolism of suga · Precise flux redistribution to glyoxylate cycle for 5-aminolevulinic a · Synthetic auxotrophs for stable and tunable maintenance of plasmid cop · Pathway optimization by re-design of untranslated regions for L-tyrosi · Application of SGT1-Hsp90 chaperone complex for soluble expression of