2D MoS2-conformal 3D-printed platform for dual-phototherapy and bone regeneration

Abstract Osteosarcoma has a poor prognosis owing to its aggressive metastasis and high recurrence rates. Consequently, recurrence due to residual cancer cells is common even after surgical resection, necessitating structural and functional reconstruction of extensive bone defects. Particularly for irregular defects, site-specific design is essential to ensure anatomical conformity, and there remains an urgent need for theragenerative approach which simultaneously provides structural reconstruction and functional eradication of residual cancer cells. Herein, a 3D-printed theragenerative polyetheretherketone (PEEK) scaffold is presented, in which a patient-specific structure is constructed from fabricated PEEK filaments and subsequently integrated with biofunctional 2D molybdenum disulfide (MoS 2 ) as a surface interface to impart enhanced bioactivity and photo-responsiveness. MoS 2 was sy…