Liquid metal-based stretchable bioelectronic fiber for electrical stimulation and drug delivery in minimally invasive cardiac therapy

Cardiovascular diseases, such as ventricular arrhythmias and heart failure, require timely and effective treatment to prevent disease progression and improve patient outcomes. Current therapeutics, including electrical shock and emergent cardiovascular medications, have significantly contributed to managing these conditions. However, due to their systemic side effects, there are ongoing demands for highly effective localized therapies. In this regard, a soft implantable device has been considered for cardiac applications, but invasiveness in their implantation procedure and difficulty in compact integration of multiple functions are unmet challenges. To address these issues, we develop a stretchable, multi-functional fiber designed for emergent cardiac intervention, offering electrogram recording, electrical modulation, and drug therapy directly at the epicardial surface. With temperatur…