Enhanced Anti‐Photoaging Effects of Adipose‐Derived Stem Cell (ADSC) Secretome via Liposomal and Iontophoretic Intradermal Delivery

Abstract The growing societal concern regarding skin aging caused by ultraviolet (UV) exposure has spurred the quest for effective therapeutic solutions. Among these, secreted factors derived from adipose‐derived stem cells (ADSC) have emerged as promising candidates with anti‐photoaging properties. The secretome of ADSC stimulates resident fibroblasts, triggering antioxidant effects and promoting the synthesis of the extracellular matrix, thus counteracting the effects of photoaging. In this study, the potential of dried ADSC secretome (AD‐Sc), obtained through a compressed fluid antisolvent process, is assessed as an anti‐photoaging agent. In addition, liposome nanocarriers are used to encapsulate AD‐Sc (Sc_Lipo) to enhance its delivery efficiency. The findings demonstrate that both AD‐Sc and Sc_Lipo effectively reduce reactive oxygen species levels in UV‐damaged human fibroblasts, upr…