Bioactive magnesium-based whitlockite ceramic as bone cement additives for enhancing osseointegration and bone regeneration

PMMA bone cement is commonly used in the field of orthopedics as a filling material. However, due to the lack of biological activity and high elastic modulus, its application scope and efficacy are greatly limited, such as in the treatment of osteoporotic vertebral compression fractures(OVCF). For this reason, new functional bone cement was synthesized and designed to address and improve those shortcomings. In this study, Tetracalcium phosphate (TTCP) and Whitlockite (WH) were incorporated with PMMA cement to prepare a novel bone cement (TTCP/WH) and systemically evaluated its characteristics such as the operational working time and mechanical properties, etc. based on the International Standardization Organization standard (ISO 5833). Also, the biocompatibility and osteogenic activity of TTCP/WH bone cement were analyzed in vitro, and the rabbit ilium bone defect model was also used to …