High-Efficient Production of Adipose-Derived Stem Cell (ADSC) Secretome Through Maturation Process and Its Non-scarring Wound Healing Applications
2021 · Frontiers in Bioengineering and Biotechnology
저자
Young‐Hyeon An, Dae‐Hyun Kim, Eun Jung Lee, Dabin Lee, Mihn Jeong Park, Junghyeon Ko, Dongwook Kim, Jiwan Koh, Hyun Sook Hong, Youngsook Son, Je-Yoel Cho, Ji‐Ung Park, Sun-Dong Kim, 황석연 (Nathaniel Suk-Yeon Hwang)
연구주제
Wound Healing and Treatments · Mesenchymal stem cell research
NTIS 과학기술표준분류
가장 가까운 분류(보건의료 > 신약·의약품개발 > 세포/조직치료제)가 화학·화공 범위 밖이다. 배정 근거: 지원 과제의 분류와 AI 키워드가 잡은 과제의 분류를 반씩.
AI 연구 키워드·방법
지방유래 줄기세포(ADSC) scarless wound healing stem cell secretome
proteomic analysis
키워드 (OpenAlex)
adipose-derived stem cells stem cell secretome scar reduction full-thickness skin defect angiogenesis epithelial regeneration extracellular matrix proteins growth factors
초록
Recently, the stem cell-derived secretome, which is the set of proteins expressed by stem cells and secreted into the extracellular space, has been demonstrated as a critical contributor for tissue repair. In this study, we have produced two sets of high concentration secretomes from adipose-derived mesenchymal stem cells (ADSCs) that contain bovine serum or free of exogenous molecules. Through proteomic analysis, we elucidated that proteins related to extracellular matrix organization and growth factor-related proteins are highly secreted by ADSCs. Additionally, the application of ADSC secretome to full skin defect showed accelerated wound closure, enhanced angiogenic response, and complete regeneration of epithelial gaps. Furthermore, the ADSC secretome was capable of reducing scar formation. Finally, we show high-dose injection of ADSC secretome via intraperitoneal or transdermal deli…
이 논문을 지원한 국가R&D 과제 (NTIS 성과)
| 연도 | 과제 | 부처 | 사업 | 수행기관 | NTIS 분류(1순위) |
|---|---|---|---|---|---|
| 2021 | 미래 수의학 선도 교육연구단 | 교육부 | 4단계두뇌한국21사업(R&D) | 서울대학 | – |
| 2021 | 화공분야연구인력양성사업단 | 교육부 | 4단계두뇌한국21사업(R&D) | 서울대학 | – |
| 2021 | 세포 표면 나노코팅 및 세포 내 소기관 강화 기술을 기반으로 한 차세대 베타세포 치료제 개발 | 과학기술정보통신부 | 바이오.의료기술개발(R&D) | 이화여자대학 | 범위 밖 |
인접 그래프
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